Scientific Programme
Monday, November 21st, 2022
15:00 – 16:30 Registration
16:30 – 17:00 Welcome address and meeting rationale
Giacinto Bagetta, Chairman of Preclinical and Translational Pharmacology, University of Calabria (Rende, Cosenza)
Maria Luisa Panno, Head of Department of Pharmacy, Health Science
and Nutrition, University of Calabria (Rende, Cosenza)
Sebastiano Andò, Emeritus of General Pathology, University of Calabria (Rende, Cosenza)
Giovambattista De Sarro, Rector, University Magna Graecia (Catanzaro)
17.00 – 17:15 Introduction
Giorgio Racagni, President of Italian Society of Pharmacology (SIF, Milan)
17:15 – 18:00 Opening lecture
Pierluigi Nicotera (Scientific Director and Chairman of the Executive Board, DZNE, Bonn)
Research at DZNE: a cooperative national organization to fight neurodegeneration
18:00 – 19:00 Welcome Cocktail
Tuesday, November 22nd, 2022
9:30 – 9:35 Introduction
Giambattista Bonanno (Genoa)
9:35 – 10:00
Monica di Luca (Milan)
Synaptic dysfunction in Alzheimer disease
10:00 – 11:00
1st COMMUNICATIONS SESSION: Basic Research in Dementia
Chairpersons: Diana Amantea (Rende, Cosenza) & Luigi Brunetti (Chieti)
Daniele Bano (Bonn)
Mitochondria in longevity and age-related processes
Giuseppe Passarino (Rende, Cosenza)
The effects of gene interactions on cognitive decline and dementia
Elisa Landucci (Florence)
Cannabinoid mechanisms in models of neurodegenerative disorders in vitro
Giuseppe Pignataro (Naples)
Nanoparticle-mediated delivery of a new TSPO ligand suppresses inflammation in LPS-stimulated microglia and in a mouse model of Alzheimer’s disease
11:00-11.30 Coffee break
11:30 – 11:35 Introduction
Lucio Annunziato (Naples)
11:35 – 12:00
Marzia Perluigi (Rome)
Impairment of redox homeostasis and energy metabolism in the brain of Down syndrome: a synergistic path to Alzheimer disease
12:00 – 13:00
2nd COMMUNICATIONS SESSION: Basic Research in Dementia
Chairpersons: Anna Pittaluga (Genoa) & Rossella Russo (Rende, Cosenza)
Antonella Scorziello (Naples)
NCX3-induced mitochondrial dysfunction in midbrain leads to neuroinflammation in striatum of A53T-a-synuclein transgenic old mice
Kengo Hamamura (Fukuoka)
Novel enhancement mechanisms of the nociceptive response by serum exosomes in a mouse model of neuropathic pain
Livio Luongo (Naples)
Neuroplastic changes in beta amyloid-induced Alzheimer like phenotype are associated with social and cognitive impairment
13:00-15:30 Lunch break and Poster presentation
15:30 – 15:35 Introduction
Luigi A. Morrone (Rende, Cosenza)
15:35 – 16:00
Sabatino Maione (Naples)
New technologies unveil future resources from the glorious past of the natural substances
16:00 – 17:00
3rd COMMUNICATIONS SESSION: Translational Research in Dementia
Chairpersons: Francesca Luisa Conforti (Rende, Cosenza) & Fabio Blandini (Pavia)
Carmela Matrone (Naples)
The amyloid precursor protein phosphorylation at the tyrosine 682 residue as druggable signature in Alzheimer disease
Alessandra Roggeri (Genoa)
The complex mode of action of anti-NMDA and anti-AMPA antibodies in the CNS: translations to clinical disorders
Barone Eugenio (Rome)
Neural-derived extracellular vesicles (nEVs): a novel approach to identify brain alterations leading to Alzheimer disease
17:00 – 17:30 Coffee break
17:30 – 17:35 Introduction
Domenico Pellegrini Giampietro (Florence)
17:35 – 18:00
Tsukasa Sakurada (Fukuoka)
Pharmacological characterization of bergamot essential oil for clinical use
18:00 – 19:00
4th COMMUNICATIONS SESSION: Translational Research of Natural Products for Dementia
Chairpersons: Mario Dell’Agli (Milan) & Carmela Fimognari (Bologna)
Rosmara Infantino (Naples)
2-pentadecyl-2oxazoline (PEA-OXA) treatment reduces cognitive impairments in a mouse model of dementia
Francesca Calabrese (Milan)
Effects of chronic treatment with a phytosomal preparations containing Centella asiatica L. and Curcuma longa L. on cognitive performance in rats: involvement of neuroplastic mechanisms
Franca Marino (Varese)
Effect of cannabidiol on human immune cells: relevance for neuropathic pain and inflammatory diseases
Wednesday, November 23rd, 2022
9:30 – 9:35 Introduction
Giacinto Bagetta (Rende, Cosenza)
9:35 – 10:00
Daniela Galimberti (Milan)
Dementia therapeutics: Biotech drugs
10:00 – 11:00
1st COMMUNICATIONS SESSION: Clinical research
Chairpersons: Amalia Bruni (Lamezia Terme, Catanzaro) & Pierluigi Nicotera (Bonn)
Antonio Leo & Martina Tallarico (Catanzaro)
Alzheimer disease and epilepsy: Current concepts and overlapping therapeutic strategy
Francesco Garaci (Rome)
Imaging of dementia and artificial intelligence (AI)
Carlo Nucci (Rome)
Imaging biomarkers for Alzheimer’s Disease and Glaucoma: current and future practices
11:00-11.30 Coffee break
11:30 – 11:35 Introduction
Paolo Tonin (Kroton)
11:35 – 12:00
Linda Claire (Exeter)
Cognitive rehabilitation for people with dementia
12:00 – 13:00
2nd COMMUNICATIONS SESSION: New Trends in Dementia Rehabilitation
Chairpersons: Dafin Muresanu (Cluj-Napoca) & Sara Bottiroli (Pavia)
Dafin Muresanu (Cluj-Napoca)
The concept of neurobiological reserve and the impact on neurorehabilitation research paradigm
Stefano Cappa (Pavia)
Management of neurodegenerative language disorders
Damiana Scuteri (Rende, Cosenza)
Targeting pain to control neuropsychiatric symptoms of dementia: the need for tailored clinical trials
Francesco Riganello (Kroton)
Importance of the autonomic and behavioral response in the assessment of pain in patients with disorders of consciousness
13:00-14.30 Lunch
Poster Communications
Presynaptic complement, a synaptic organizer in the CNS: relevance to synaptopathy.
Guendalina Olivero, Francesca Cisani, Alessandra Roggeri, Giulia Vallarino, Alice Taddeucci, Hanna Trebesova, Massimo Grilli, Lorenzo di Cesare Mannelli, Carla Ghelardini, Anna Pittaluga
Impact of early acute inflammation on the development of the GABAergic system in the hippocampus: aging and sex dependency.
Alessandra Roggeri, Alice Taddeucci, Cristina Ceccoli, Giulia Vallarino, Guendalina Olivero, Cristina Benatti, Joan MC Blom, Fabio Tascedda, Nicoletta Brunello, Anna Pittaluga
Nutraceutical approaches for the management of aging: promising antiaging activity of a new formulation of ellagic acid.
Alice Taddeucci, Giulia Vallarino, Alessandra Roggeri, Guendalina Olivero, Veronica Torre, Federica Turrini, Maria Summa, Rosalia Bertorelli, Raffaella Boggia, Anna Pittaluga
Anxiolytic-like/relaxant effects of BEO are useful to manage anxiety and agitation symptoms observed in patients with dementia
Laura Rombolà, Damiana Scuteri, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone
Role of mGlu-5 and mGlu2/3 receptors in behavioural effects of bergamot essential oil
Laura Rombolà, Enrica De Rasis, Damiana Scuteri, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone
2-pentadecyl-2-oxazoline (PEA-OXA) treatment reduces the cognitive damage and impaired neural plasticity in vitamin D deficiency.
Belardo C., Iannotta M., Manzo I., Infantino R., Boccella S., Ricciardi F., Perrone M., Fusco M., Ricciardi F., Maione S. and Guida F.
Role of spinal cholecystokinin-8, nociception and hemokinin-1 in diabetic allodynia.
T. Hayashi, S. Kanno, C. Watanabe, Y. Agatsuma, A. Hara, T. Sakurada, S. Sakurada
Hemokinin-1 activates transient receptor potential vanilloid 1 channels in the spinal cord to induce nociceptive behavior.
T. Hayashi, S. Kanno, C. Watanabe, Y. Agatsuma, A. Hara, T. Sakurada, S. Sakurada
Pain assessment for better pharmacological treatment of pain and agitation in severe dementia: I-MOBID2 validation
D. Scuteri, M. Contrada, T. Loria, D. Sturino, A. Cerasa, P. Tonin, G. Sandrini, S. Tamburin, A.C. Bruni, P. Nicotera, M.T. Corasaniti, G. Bagetta
Need for a clinical trial investigating efficacy and safety of oral spray nabiximols for pain and agitation treatment in severe dementia patients
D. Scuteri, F. Guida, S. Boccella, L. Luongo, S. Maione, P. Tonin, P. Nicotera, G. Bagetta, M.T. Corasaniti
Automated Diagnosis of Alzheimer’s disease with neuropsychological measures: a meta-analytical review
A. Cerasa, P. Battista, C. Salvatore, M. Berlingeri, I. Castiglioni